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Janis POLIS


Janis POLIS


Born: June 25, 1938, Jelgava district, Eleja civil parish, Latvia
Died: April 12, 2011, in Riga






Interests in inventing:

  • Synthesis of new potentially biologically active derivatives of adamantane
  • New methods for obtaining already known derivatives of adamantane that serves the synthesis of medical materials

Main invention:

 

  • Acetyladamantane (adamantylmethylketone) transforms into remantadin (alpha-methyl-1-adamanyilmethylaminochlorhydrate) - 3 authors’ certificates of USSR

Selection of patent documents:

Totally: 36 authors’ certificates of USSR and patents of other countries

Remantadin:

    Authors’ certificates of USSR Nr. 309600 (1971), C 07c 87/06; C07c 85/86; Nr. 383369 (1973), C 07c 87/06; C07c 85/08; Nr.465397 (1974), C 07c 87/06; C07c 85/08.

Methods for the synthesis of acetyladamantane:

  • Co-authors: I.Grava, D.Kruskopa. Authors’ certificate of USSR Nr. 440059 (1974). C 07c 49/36
  • Co-author D.Kruskopa.Authors’ certificate of USSR Nr. 522596 (1976).
  • Co-authors: I.Lazdins, P.Avots, A.Avots, V.Aizbalts, V.Satcs. Authors’ certificate of USSR Nr.790610 (1980). C07c 49/453; C07c 45/00
  • Co-authors: I.Lazdins, P.Avots, A.Avots, V.Aizbalts, V.Belikovs, I.Penke. Authors’ certificate of USSR Nr.799312 (1980). C07c 45/45; C07c 49/15.

Method for the synthesis of 1-adamantanecarcoxylic acid (starting material of acetyladamantane):

  • Co-author B.Raguele. Authors’ certificate of USSR Nr.401132 (1973). C07c 61/28;
  • Co-authors: B.Raguele, B.Vilne. Authors’ certificate of USSR Nr. 583999 (1977). C07c 61/12.

Method for obtaining the starting material of adamantane:

  • Co-authors: V.Kuplenieks, I.Lazdins, P.Avots, A.Avots, G.Kumerovs, J.Melbergs, I.Penke, V.Strazdina. Authors’ certificate of USSR Nr. 679564 (1978).C07c 13/54.

Methods for obtaining new biologically active derivatives of adamantane:

  • Co-author M.Lidaks. Authors’ certificate of USSR Nr. 25014 (1969). C07d; 12p 7/01.
  • Co-author B.Vilne. Authors’ certificate of USSR Nr.276064 (1970). C07; 12p,3.
  • Co-author S.Hillers. Authors’ certificate of USSR Nr.276937 (1970);
  • Co-authors: S.Hillers, I.Komjanovs. Authors’ certificate of USSR Nr. 1179997 (1985).

The obtained product became a preparation “Glutandan” possessing medicational characteristics in case of influenza and parkinsonism. It is patented in USA, England, France, VFR and Japan.

New methods for obtaining already known derivatives of adamantane:

  • Co-author B.Raguele. Authors’ certificate of USSR Nr.304248 (1971).
  • Authors’ certificate of USSR Nr.408546 (1973), Nr.581943 (1977). The preparation has been introduced in the Pharmaceutical plant in Olaine under the name of “Midantan” (a preparation for the medication and prevention of bird influenza).

Drugs for medication and technics:

  • Co-authors: V.Larikovs, N.Teterina, G.Konovalova. Authors’ certificate of USSR Nr.709177 (1979).
  • Co-authors: E.Bisenieks, N.Barmenkova, J.Uldrikis, G.Duburs a.o. Authors’ certificate of USSR Nr.963246 (1981).
  • Co-authors: E.Bisenieks, N.Barmenkova, J.Uldrikis, G.Duburs a.o. Authors’ certificate Nr. 1044001(1983).
  • Co-authors: E.Bisenieks, N.Barmenkova, J.Uldrikis, G.Duburs, M.Veveris. Authors’ certificate of USSR Nr.1095599 (1984). Patented in Russia as a preparation «Adapiron».

About the inventions

Implementation:

During the 70ties these inventions were patented in USA, England, FRG, France, Belgium, Switzerland, India and Japan. Following the method of these inventions Olainfarm in Latvia is now producing Remantadin.

The essence of the invention:

Remantadin is obtained in a reaction of acetyladamantane with amides in the presence of formic acid. Remantadin has effect on the virus-specific enzyme that is responsible for the synthesis of nucleic acids in a cell.

More about the inventor (in Latvian)

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