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Pauls PUMPENS


Pauls PUMPENS
Professor, Scientific director
Latvian Biomedical Research and Study Centre
University of Latvia
Ratsupites street 1
Riga, LV 1067, Latvia
 
Phone: +371 67808214
Fax: +371 6744 2407
E-mail:
paul@biomed.lu.lv
Born: October 21, 1947 in Riga, Latvia.






Interests in inventing:

  • Gene and protein engineering
  • Construction of vaccine prototypes

Main invention:

  • in gene engineering
Cloning of viral (hepatitis B and C, RNA bacteriophages, and other) genomes and expression of their genes in recombinant expression systems (bacteria, yeast, eukaryotic cell lines). One of the first cloned and sequenced hepatitis B virus (HBV) genomes - the so-called Latvian HBV320 genome. It has become the subject of very many theoretical works and the basis of several HBV vaccines in different countries (together with T.Kozlovska, A.Dislers, V.Bichko, R.Kukaine and E.Grens). The first direct expression of the HBV surface antigen (HBsAg) gene and one of the first expressions of the HBV core antigen (HBcAg) gene in bacteria, construction of the bacterial HBcAg superproducers (together with T. Kozlovska, G.Borisova, A.Dislers, V.Tsibinogin, E.Grens, and others). Cloning and expression of the hepathitis C virus (HCV) genes (together with I. Sominskaya and T. Kozlovska). Creation of a replication model of RNA bakteriophages (together with V. Baumanis, A. Dislers, and E. Grens). Expression of coat protein (CP) genes of a set of RNA bacteriophages, construction of superproducers of RNA bacteriophage CP in bacteria and yeast (together with A.Dislers and A.Kazaks).
  • in protein engineering
The elaboration of the idea and creation of a basis for protein engineering of virus-like particles (VLPs) (together with E. Grens). Mapping of immune epitopes of viral proteins (together with P. Pushko and I. Sominskaya). Selection of VLP protein engineering carriers; construction of chimeric VLPs on their basis. HBcAg – created as a universal VLP carrier – basis of the traditional chimeric VLP structures; introduction of foreign epitopes into the HBcAg – from HIV, HBV, HCV, FMDV and many other proteins of virual and non-viral origin (together with G. Borisova, I. Sominskaya, A. Dislers, I. Petrovskis, A. Kazaks, K. Sasnauskas, R. Ulrich, H. Meisel, and others). Resolving of HBcAg spatial structure (together with R. A. Crowther, N. Kiselev, E. Grens, and others). Identification and employment of the HBcAg packaging features (together with M. Bachmann and A.Kazaks). Elucidation of HBcAg immunological features (together with R. M. Zinkernagel, D. Skrastina, G. Mezhule, E. Grene, and others). Introduction of RNA bacteriophage CP genes into universal carriers of VLP protein engineering (together with P. Pushko, T. Kozlovska, I. Sominskaya, I. Cielens, R. Renhofa, A. Dislers, and others). Determination of spatial structure of RNA bakteriophages (together with L. Liljas, M. Bundule, K. Tars, and others). Implementation of plant virus (together with A. Zeltins) and papovavirus nucleocapsids (together with T. Voronkova and A. Kazaks) in the VLP protein engineering.
  • In contruction of vaccine prototyps
Construction of vaccine prototypes and gene therapy tools – against hepatitis B and C, as well as other infectious and non-infectuous diseases – several EU projects of bilateral cooperation (together with W. H. Gerlich, R. M. Zinkernagel, M. Roggendorf , M. Nassal, D. Klatzmann, and others). Creation of a replication model of HBV with the help of alfaviral vectors (together with T. Kozlovska, A. Zajakina, R. Bruvere, and others). Immunological screening of vaccine prototypes (together with D. Skrastina). Recent project – construction of hepatitis C vaccine prototypes in frame of the European integrated project Compuvac.

About the inventions

It is impossible for a scientist not to be an inventor but an inventor is not obligatory a scientist.
It is bad that scientists have to be the implementors of their own inventions – it shortens their scientific life.

 More about the inventor (in Latvian)

More about the inventor (in English)

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